What is CJD?

CJD and Prion Disease

CJD (Creutzfeldt-Jakob Disease) is a degenerative brain disorder caused by misfolded prion proteins, which destroy brain cells. The disease is rapidly progressive and leads to death usually within 1 year of onset of illness and often much sooner. Currently, CJD is responsible for 1 in 5000 deaths in the UK.

CJD has three main types

There are 3 main types of CJD: sporadic, inherited and acquired.

Sporadic CJD

Sporadic CJD occurs at random in the population as an unlucky chance event.

Inherited CJD

Inherited CJD is caused by a faulty gene passed down in families.

Acquired CJD

Acquired CJD is caused when a person is infected with prions from an outside source.

Finding a treatment for CJD

World leading research at the MRC Prion Unit at UCL developed an experimental antibody treatment called PRN100. This was designed to stop prion proteins from malfunctioning in the brain.

Positive results were shown in laboratory testing and a small number of patients were given PRN100 in an experimental treatment programme in 2018/2019.

Finding a treatment for CJD

World leading research at the MRC Prion Unit at UCL developed an experimental antibody treatment called PRN100. This was designed to stop prions from malfunctioning in the brain.

Positive results were shown in laboratory testing and a small number of patients were given PRN100 in an experimental treatment programme in 2018/2019.